Dentifrices containing alpha-alumina trihydrate

ABSTRACT

Toothpaste containing abrasive particles of milled alpha-alumina trihydrate, alkali metal monofluorophosphate and alkali metal fluoride, the total fluoride corresponding to about 500 to 1000 ppm F, which toothpaste is compatible with an unlined aluminum container and is effective to reduce enamel solubility.

This is a continuation, of application Ser. No. 50,935 filed June 21,1979, which is a continuation of Ser. No. 871,677, filed Jan. 23, 1978,which is a continuation of 766,658, filed Feb. 8, 1977, now abandoned,which is a continuation of Ser. No. 640,663, filed Dec. 15, 1975, nowabandoned.

This invention relates to dentifrices, particularly toothpastes.

Certain aspects of the invention relate to toothpaste formulationscontaining highly alkaline milled Bayer process alpha-aluminatrihydrates. It is found that such toothpaste formulations when packedin unlacquered aluminium tubes react with the aluminium walls of thetube to form gas on storage, even when the pH of the toothpaste issubstantially neutral, e.g. 7.1. It has now been found that suchreaction on the aluminium walls of the tube may be prevented simply byadjusting the pH of the toothpaste prior to storage to a value in therange of about 5.4 to 6.6 or 6.7, preferably about 5.4 to 6.1 or 6.2.The pH may be adjusted by means of an organic carboxylic acid such asbenzoic, citric, tartaric malic, acetic acid, propionic acid or othersuitable (e.g. non-toxic) acidic material, such as sodium bisulphate,aluminium fluoride, aluminium sulphate or zinc sulphate.

The highly alkaline milled Bayer process alpha-alumina trihydrate is onewhich in a 10% slurry in deionized water gives a pH of above about 8.5(such as about 8.8 or more). When used in toothpaste formulation A, setforth below, it may yield a toothpaste having an initial pH (beforestorage) of at least about 6.9. At such pd or higher (e.g. initial of pH7.1 or 7.3) the resulting toothpaste, when packed in an unlinedaluminium tube, gives visible gas formation accompanied by bloating ofthe tube on storage at 100° F. (38° C.) for 3 months.

    ______________________________________                                        TOOTHPASTE FORMULATION A                                                      ______________________________________                                        Milled alpha-alumina trihydrate                                                                        55%                                                  70% aqueous solution of sorbitol                                                                       27%                                                  Sodium carboxymethyl cellulose                                                                         0.8%                                                 Sodium lauryl sulphate   1.5%                                                 Titanium dioxide         0.5%                                                 Saccharin                0.2%                                                 Benzoic acid             0.15%                                                Flavour                  1.0%                                                 Water                    Balance                                              ______________________________________                                    

All proportions herein are by weight unless otherwise indicated.

The foregoing formulation may be made in a conventional manner as bymixing the humectant (sorbitol), gelling agent (dentifrice grade sodiumcarboxymethyl cellulose) and water, adding saccharin, benzoic acid andflavour, then adding the abrasive (alpha-alumina trihydrate), includingthe finely divided titanium dioxide whitener, deaerating, and mixing inthe detergent (sodium lauryl sulphate). Thus a pre-mix of the sodiumcarboxymethyl cellulose, benzoic acid, titanium dioxide and saccharinmay be prepared, then added to the aqueous sorbitol with agitation,mixed thoroughly with high agitation for 15 minutes, after which thewater is added and the mixing is continued for another 15 minutes ormore until a smooth lump-free dispersion is obtained; the resultingblend is placed in a vacuum mixing vessel and the alumina trihydrate isdrawn into the blend under vacuum while mixing slowly, then the degreeof vacuum is increased and mixing at high speed is carried out under thehigh vacuum for 30 minutes, after which the vacuum is broken, the sodiumlauryl sulfate (in solution in water) is added, the high vacuum isrestored and the mixing is continued for another 10 minutes; the sameprocedure as used for the addition and blending of sodium lauryl sulfateis then used for the incorporation of the flavor.

Alkaline alpha-alumina trihydrates which cause corrosion at neutral pHare described, for instance, at page 1 of German OS No. 2509399published Sept. 11, 1975.

One particular highly alkaline milled Bayer process material is thematerial made by Baco (British Aluminium Company) and sold under thedesignation AF 260. A typical sample of this material showed a pH ofabout 9.5 when dispersed in water at 20% concentration. When a typicalsample of this material was incorporated into the previously mentionedtoothpaste formulation A but without the 0.15% benzoic acid it was foundthat the initial pH of the formulation was about 8.1. When this samematerial was incorporated into that toothpaste formulation A containingthe 0.15% benzoic acid, the initial pH of the formulation was about 7.3;on storage for three months at 110° F. (43° C.) considerable gassingoccurred. When the total amount of benzoic acid in the formulation wasincreased to 0.26% the initial pH of the formulation was about 6.3; onstorage for 3 months at 110° F. (43° C.) no gassing was observed.

The highly alkaline milled alpha-alumina trihydrate generally has anaverage particle size in the range of about 2 to about 15 microns.Typically it has a relatively large proportion (such as 40% or 50% ormore) of particles smaller than 7.9 microns and may have a low finescontent, such as not more than 20% by weight smaller than 3 microns.Thus, one sample of Baco AF260 has the following typical approximateparticle size distribution (measured by Coulter counter) 20% finer than5 microns, 40% finer than 7.5 microns, 58% finer than 10 microns, 82%finer than 15 microns, 91% finer than 20 microns, with a mean particlesize of 8 microns, and at most 0.1% retained on a BSS 350 45 microns)sieve. A typical chemical analysis of the Baco AF 260 material is65.5±0.5% Al₂ O₃, 34.5±0.5% lost on ignition at 1150° C., 50 ppm maximumheavy metals calculated as Pb, 5 ppm maximum Pb, 1 ppm maximum arsenic,0.35% Na₂ O.

In measuring the pH of a slurry of the milled alphaalumina trihydratethe mixture of the solid and deionized water is stirred for 5 minutesand then a conventional pH meter is introduced while stirring iscontinued to maintain a substantially uniform slurry. The measuringinstrument may be, for instance, an EIL model 1150 combination pHelectrode connected to an Orion model 801 digital pH/mV meter; this mayalso be employed for measuring the pH values of the toothpastes.

Another aspect of the invention relates to toothpaste formulationscontaining the highly alkaline milled alphaalumina trihydrate inadmixture with sodium fluoride. It is found that such inclusion ofsodium fluoride in the toothpaste results in a chemical reaction whichraises the pH. For instance, when 0.24% by weight of sodium fluoride wasincorporated into a toothpaste containing 0.2% benzoic acid (ordinarilysufficient to give a toothpaste pH of less than about 7, as indicatedabove) the pH of the toothpaste was found to be about 8.2. The additionof more benzoic acid (e.g. to raise the benzoic acid content to 0.50%giving a pH of 6.20) did not overcome the tendency to react with thetube walls; considerable gassing occurred on storage as described above.It is found, however, that when the fluoride content is supplied by amixture of sodium monofluorophosphate ("MFP") and sodium fluoride, in aMFP:NaF mol ratio of more than 1:1 the reactive tendency is inhibited.The MFP:NaF mol ratio is preferably at least about 1.5:1 and less thanabout 10:1, such as about 2:1, 3:1, 4:1, 5:1, 6:1, 7:1, 8:1 or 9:1. Thetotal proportion of soluble fluoride (e.g. MFP calculated as F plus NaFcalculated as P) added to the toothpaste is preferably no more thanabout 1500 ppm, and at least about 500 ppm, most preferably in the rangeof about 800 to 1100 ppm, e.g. about 1000 ppm.

It is also found unexpectedly that in these MFP-NaF formulations the useof the highly alkaline milled alpha alumina trihydrate results ingreater retention of soluble fluoride than when less alkaline milledalpha alumina trihydrate is employed, at the same initial pH of thetoothpaste.

Furthermore, use of such formulations permits the solubility of dentalenamel to be substantially reduced, particularly as compared to aformulation containing complex fluoride (e.g. MFP as the only source offluoride. Thus, enamel solubility is reduced compared with the situationin which MFP is the sole fluoride source; while avoiding gassingnormally occurring in formulations containing alkali metal fluoride asthe sole fluoride source. The following Examples illustrate the use ofblends of MFP and NaF.

EXAMPLE 1

A toothpaste formulation is prepared in a conventional manner by mixingthe following ingredients: glycerol 20.2%; sodium carboxymethylcellulose 1.1%, saccharin 0.2%, benzoic acid 0.29%, Baco AF 260 51.5%,titanium dioxide 0.5%, sodium monofluorophosphate (a technical gradecontaining about 94% sodium monofluorophosphate, together withhydrolysis products thereof such as NaF, phosphates, etc.) 0.82% (about1000 ppm F): sodium fluoride 0.12% (about 500 ppm F); sodium laurylsulphate 1.5%, flavour 0.8%; balance water. The initial pH of thetoothpaste is 6.7. On storage in unlined aluminium tubes for 3 months at110° F. (43° C.) it shows a very good fluoride retention and the tubesare not swollen.

EXAMPLES 2-6

Example 1 is repeated except that the proportions of MFP, NaF andbenzoic acid, and the initial pH, are as follows:

    ______________________________________                                                MFP   NaF     Mol     Initial                                                                              % Benzoic                                        ppm F ppm F   Ratio   pH     Acid                                     ______________________________________                                        Example 2 900     100     9:1   6.7    0.250                                  Example 3 860     200     4:1   6.3    0.313                                  Example 4 700     300     2.33:1                                                                              6.5    0.317                                  Example 5 600     400     1.5:1 6.3    0.380                                  Example 6 0       1000    0     6.2    0.50                                   ______________________________________                                    

In each of Examples 2 to 5 the storage (as in Example 1) does not resultin gassing and the soluble fluoride content after such storage ismeasured at over 700 ppm. In the comparison Example 6, the tubes gasseverely on such storage and the measured soluble fluoride content ismarkedly lower.

From the foregoing it will be observed that the use of sodium fluoridein the toothpaste containing alpha-alumina trihydrate of high alkalinitytends to cause attack of unlined aluminum tubes even when the initial pHof the toothpaste is such that attack would be inhibited in the absenceof the sodium fluoride. When the proportion of sodium fluoride is suchas to provide about 500 ppm F (as in Example 1) but the proportion ofMFP is lower than that in Example 1 (i.e. a proposition such as toprovide about 500 ppm F, rather than the 1000 ppm F of Example 1) theresults have been borderline; thus in two experiments (using the sameformulation, except as noted below) in which the molar ratio was 1:1,specifically using amounts of MFP and NaF which each provided 500 ppm F(for a total of 1000 ppm F as in Examples 2 to 6), no gassing wasobserved when the amount of benzoic acid was 0.40% and the initial pHwas 6.6 while severe gassing was observed (under the same 43° C. 3-monthstorage conditions) when the amount of benzoic acid was 0.33% and theinitial pH was 6.4.

As a further aspect of this invention it has been found, quiteunexpectedly, that when the toothpaste contains a detergent comprising acarboxylic acid having a long aliphatic hydrocarbon chain attached tothe carboxyl through an amide linkage, in place of the sulfoxydetergent, the attack on the unlined aluminum tube is inhibited evenwhen the sodium fluoride is used as the sole source of fluoride and ispresent in relatively large amounts. The use of this detergent isillustrated in Examples 7-10 below.

EXAMPLES 7-10

Example 1 is repeated except that the 1.5% sodium lauryl sulfate isreplaced by 2% sodium N-lauroyl sarcosinate and the proportions of MFP,NaF and benzoic acid, and the initial pH, NaF and benzoic acid, and theinitial pH, are as follows:

    ______________________________________                                               MFP   NaF                 % Benzoic                                           ppmF  ppmF      Initial pH                                                                              Acid                                         Example 7                                                                               500     500      6.5     0.40                                       Example 8                                                                              0       1000      6.8     0.50                                       Example 9                                                                              1000     500      --      0.33                                       Example 10                                                                             0       1500      6.3     0.80                                       ______________________________________                                    

In each of Examples 7 to 10 the storage (as in Example 1) does notresult in gassing, and measurements of soluble fluoride after suchstorage indicate good fluoride retention.

It is also found that the use of the detergent which is a fatty acidinterrupted by an amide linkage, in place of the sulfoxy detergent, alsohas a beneficial effect when the alphaalumina trihydrate is of a lessalkaline type. One example of such a material is Alcoa C-333 a productof Alcoa (Aluminium Company of America). Its specifications state thatits average particle size is about 6.5-8.5 microns and, by hydrometeranalysis, 94-99% is below 30 microns, 85-93% is below 20 microns, 56-67%is below 10 microns and 28-40% is below 5 microns. Other typicalproperties as given by the manufacturer are Al₂ O₃ 65.0% (64.5%minimum), SiO₂ 0.01% (0.02% maximum), Fe₂ O₃ 0.005% (0.005% maximum),Na₂ O 0.15% (0.25% maximum), soluble Na₂ O (by standard Alcoa testmethods) 0.02% (0.04% maximum), moisture (110° C.) 0.4% (0.70% maximum),bulk density (loose) 44 lb/ft³, bulk density (packed) 77 lb/ft³,specific gravity 2.42, screen analysis 99% through 325 mesh sieve (58%minimum). Its pH, measured in a 20% slurry in deionized water is usuallyabout 8.5 or less. When this material is employed in toothpasteformulation A, given above, it typically yields a toothpaste having aninitial pH well below 6.7, such as about 6.2. Examples 11 to 14 belowrelate to this aspect of the invention.

EXAMPLES 11-14

Example 1 is repeated except that the 51.5% Baco AF-260 and 0.5%titanium dioxide are replaced by 52% Alcoa C-333, the 1.5% sodium laurylsulfate is replaced (in Examples 11 and 12) by 2% sodium N-lauroylsarcosinate and the proportions of MFP, NaF and benzoic acid, and theinitial pH, are as follows:

    ______________________________________                                               MFP     NaF                 % Benzoic                                         ppmF    ppmF    Initial pH  Acid                                       ______________________________________                                        Example 11                                                                             0         1500    6.3        0.833                                   Example 12                                                                             500        500    6.8       0.40                                     Example 13                                                                    (sodium                                                                       lauryl sulfate)                                                                        0         1000    6.4       0.50                                     Example 14                                                                    (sodium                                                                       lauryl sulfate)                                                                        0         1000    6.5       0.63                                     ______________________________________                                    

Storage (as in Example 1) does not result in gassing for Examples 11 and12 (containing the N-lauroyl sarcosine) but results in severe gassingfor Examples 13 and 14.

With respect to the fluoride retention on such storage it issignificantly better when the more alkaline grade (of Examples 1 to 10)is used than when the less alkaline grade (of Examples 11 to 14) isemployed.

In these Examples the fluoride compounds are included, as dry powders,in the pre-mix (with benzoic acid) as mentioned above. They may be addedin other ways, as in the aqueous solution of the detergent which isincorporated after the alumina trihydrate has been added.

It will be noted that the Baco trihydrate, which appears to be somewhatless reactive with the fluoride, has a lower fines content than theAlcoa trihydrate and thus may have a smaller surface area for reaction.The manufacturer of Baco AF-260 has advised that its surface area (asmeasured by light extinction) is well below 1.5 m² /g, specificallyabout 1.0-m² /g e.g. 1.1 m² /g. The manufacturer of Alcoa C-333 hasadvised that its surface area (as measured by BET nitrogen adsorption)is about 2-2.5 m² /g. The light extinction method for measuring specificsurface is described at pages 10-12 of the publication "The PhysicalExamination of Alumina" published by B.A. Chemicals Ltd., London, whichteaches that the method correlates well with other procedures.

Another aspect of the invention relates to milled alpha aluminatrihydrate which has been modified during its manufacture.

A conventional way of manufacturing alpha alumina trihydrate (hereinreferred to simply as "trihydrate") is by the Bayer process. In thatprocess trihydrate is precipitated from a solution of sodium aluminate.See Encyclopedia of Chemical Technology, Kirk-Othmer, 2nd Edition, Vol.1, p. 937-941 and Vol. 2, p. 41-45, 50-51. The trihydrate isprecipitated in the form of granules or agglomerates which are too largefor general use as a dentifrice abrasive, e.g. about 40-100 micronsdiameter. Therefore, the granules or agglomerates after drying(sometimes after water-washing and drying) are ground to a suitableparticle size, e.g. to an average particle diameter in the range ofabout 2 to 20 microns, such as about 5 to 10 microns diameter.

The washed, unground granules show an alkaline reaction when slurried inwater. For instance, depending on the degree of washing before drying,the pH of a 10% or 20% by weight of trihydrate slurry at roomtemperature may be in the range of about 7.5 to 8.5, 9 or 9.5.

The pH can be measured with an Orion model 801 Digital ph/mv meter whichis filled with an EIL model 1150 Combination pH and reference electrode.The instrument is first calibrated at room temperature by placing theelectrode into 50 ml. of pH buffer solution in a 100 ml. beaker, andadjusting the calibration control until the instrument readingcorresponds to the buffer pH. The electrode is then removed, washed withdeionised water, and placed into 125 gms. of a prepared 20% slurry ofthe trihydrate sample in deionized water in a 250 ml. beaker, and its pHreading taken.

On grinding, the alkalinity, thus measured, increases and the pHmeasured (as above) of the ground, unwashed, material is generally aboveabout 8. For instance the pH on grinding may change as follows: 7.5(before grinding) to 8.8 (after grinding); 8.8 (before) to 9.2 (after).

According to one aspect of the invention a dentifrice comprises anaqueous medium or vehicle and, as an abrasive, ground trihydrate made bythe Bayer process, the grinding having been performed in the presence ofa surface-modifying agent.

It is believed that by grinding the trihydrate in the presence of asurface modifying agent, inclusions of alkali exposed by fracture of thetrihydrate granules during the grinding, or highly active sites producedby fracturing during grinding, may be brought into intimate contact withthe surface modifying agent and thereby neutralized or inactivated.

The invention reduces the risk of localized corrosion in the dentifriceduring storage.

The amount of surface-modifying agent required will generally be withinthe range from about 0.01 to 2%, such as about 0.1% or 0.5%, by weightbased on the weight of trihydrate.

Surface-modifying agents may act by deactivating reactive sites on thetrihydrate and/or forming at least a monomolecular coating on thetrihydrate, at least during the beginning of grinding. Surface-modifyingagents which may be employed are non-toxic and include organic acids,which contain a polar and non-polar group, and salts thereof, such asbenzoic acid, lauric acid, stearic acid, oleic acid, naphthenic acid,fatty acyl amides of the amino acids, such as N-lauroyl (or N-oleoyl orN-stearoyl) sarcosine, phenol and the like which have low watersolubility and salts thereof as well as solid or liquid organic acids ofgreater water-solubility such as acetic acid, propionic acid or otherlower alkyl carboxylic acids, citric acid, tartaric acid, malic acid,and salts thereof, such as alkali metal salts, e.g. sodium.Polar-non-polar carboxylic acids and salts are described in U.S. Pat.No. 2,274,521 granted Feb. 24, 1942. Inorganic acid forming salts suchas sodium bisulphate and aluminium chloride, aluminium sulphate and zincsulfate also may be employed.

Additional non-toxic surface-modifying agents which may be employedinclude mono- and polyhydric alcoholics; dentally acceptable polishingand thickening agents; and polyelectrolytes. The most preferredmaterials are those which are more acidic than the trihydrate.

Mono- and polyhydric alcohols include methanol, ethanol, n-propanol,isopropanol, n-octanol, ethylene glycol, triethylene glycol, ethyleneglycol monomethyl ether, 1-amino-2-propanol, monoethanolamine andtriethanolamine.

Dentally acceptable polishing materials which can modify the surface ofthe trihydrate include insoluble sodium metaphosphate, dicalciumphosphate, calcium carbonate and other alkali earth metal phosphates andcarbonates, sodium aluminosilicate and crystalline and colloidal silica.The surface modifying agent may be a material of very fine particlesize, e.g. less than 1 micron diameter; acidic silica particles such aspyrogenic silica, e.g. "Cabosil," may be used.

Polyelectrolytes, particularly those ionic polymeric polyelectrolytesavailable under the name Tamol, such as Tamol 731 and Tamol 850, alsocan modify the surface of the trihydrate. Polymeric carboxylic acids,such as the vinyl methyl ethermaleic anhydride copolymer, can be usedfor this purpose.

In addition to the surface modifying agents mentioned above, suitablematerials include detergents such as anionic sulphates, and phosphates,nonionic condensates including an ethylene oxide moiety and ampholyticssuch as imidazole derivatives. Typical detergents are described below.

Non-polar materials including waxes, vegetable oils, such as palm oiland hydrogenated palm oil, and hydrocarbon oils and grease, e.g. mineraloils such as liquid paraffin, e.g. light or heavy petrolatum, petroleumjelly and petroleum wax can also modify the surface of the trihydrate.

It is preferred that the amount of surface-modifying agent present be atleast that needed to form a mono-molecular coating in the trihydrateparticles, as to enter into reaction with and deactivate sites in thetrihydrate, at least during the beginning of the grinding; preferably anexcess, such as 5% (or more) excess, is used, particularly when ballmilling. The surface area of the trihydrate granules before grinding isgenerally well below 1 m² /g and it may increase during grinding toabout 1 m² /g or above, such as 1.1 to 3 or 5 m² /g or higher.

The surface modifying agent may be in liquid form at the ambientgrinding temperature. This may be for instance, a solution, a solidsurface modifying agent in a solvent therefore, or a liquid mixture ofsolid and liquid surface modifying agents, such as a 50--50 mixture ofethylene glycol and benzoic acid, mineral oil and stearic acid andmineral oil and benzoic acid. The grinding temperature is generally wellbelow 100° C. such as about 20°, 30° or 40° C. The material being groundis preferably substantially dry, e.g. its water content is preferablybelow 20% of the weight of trihydrate, such as 1% or 2%.

The grinding of the trihydrate in the presence of the surface modifyingagent may be practiced using techniques and apparatus recognised in theart. For instance, ball milling is described in "Surface Activity inFine Dry Grinding" Berry & Kamack, pages 196-202, in Solid/LiquidInterface; Cell/Water Interface (Biological) Vol. 4. Edited by J. H.Schulman (Proceedings of the Second International Congress on SurfaceActivity, London, 1957) Academic Press, New York, 1958, "GrindingLow-Soda Alumina" by Hart and Hudson, Ceramic Bulletin, Vol. 43, No. 1(1964); and U.S. Pat. No. 3,358,937 granted Dec. 19, 1967;Vibrative-Energy Milling is described in the article by Hart & Hudsonand Pin-type Milling is described in Perry, Chemical Engineers'Handbook, 5th Edition, 1073, pages 8-37 to 8-71.

The surface-modifying agent may be added to the material being fed tothe mill, may be metered into the mill itself during operation or may beadded to the wet slurry before grinding. It is also within the broadscope of the invention to add the surface modifying agent to the sizeclassification zone associated with the mill. Thus it is common to passthe product of the mill to a size classification zone (e.g. a cyclone)from which the oversize, insufficiently ground, particles are returnedto the mill for further grinding.

EXAMPLE 15

A washed unground Bayer process trihydrate of the more alkaline (Baco)type is ground in the presence of 0.5% benzoic acid and the resultingmilled trihydrate is used in a formulation as set forth in Example 1above. The pH of the toothpaste is about 6.3. On aging at 43° C. for 3months in unlined aluminium tubes only very slight gassing is observed.

EXAMPLES 16-20

Pulverisation and reduction of particle size of granules of washed Bayerprocess alumina trihydrate is affected by charging a porcelain ball millpot containing a 50% ball charge of porcelain balls ranging in diameterfrom 1 cm to 2.5 cm with the alumina trihydrate granules together with0.5% benzoic acid based on the weight of the trihydrate such that theratio of ball volume to powder volume is 2:1. Pot sizes range from 0.5liter to 30 liter depending on charge size, 1 liter is used.

The pot is sealed, and placed on a No. 2 Motorised Pascall LaboratoryBall Mill such that it rotates horizontally about its axis on a pair ofrubber covered rollers, one driven and one idler, each 131/2" long.Drive is by a 1/4 H.P. electric motor with a variable speed control. Themotor is started and the speed adjusted such that the balls tumble inthe mill pot to reduce the particle size of the trihydrate. The motor isthen stopped, the pot removed and the charge separated from the balls bysieving and then suitably classified to remove large particles, such asthose larger than 20 microns, which large particles are returned to theball mill.

    ______________________________________                                                        Example Number                                                Ingredients       16     17     18   19   20                                  ______________________________________                                        Abrasive - Ground Trihydrate                                                  prepared as above 52.0   52.0   52.0 52.0 52.0                                Humectant                                                                     Glycerine         20.0   20.0   20.0 15.0 20.0                                Sorbitol          --     --     --   5.0  --                                  Thickener                                                                     Sodium carboxymethyl cellulose                                                                  1.1    1.1    1.1  1.1  1.1                                 Flavour and Sweetener                                                         Flavour           0.8    0.8    0.8  0.8  0.8                                 Sodium saccharinate                                                                             0.2    0.2    0.2  0.2  0.2                                 Detergent (Note 2)                                                            Sodium lauryl sulphate                                                                          1.5    1.5    1.5  1.5  1.5                                 Propylactic agent                                                             Sodium monofluorophosphate                                                                      0.5    0.4    --   --   --                                  Sodium fluoride   --     0.1    0.2  --   --                                  Water             23.9   23.9   24.2 23.9 23.9                                ______________________________________                                         Note 1                                                                        In modified Examples the sodium carboxymethyl cellulose is replaced by        hydroxyethyl cellulose and by Irish Moss.                                     Note 2                                                                        In other modified Examples the sodium lauryl sulphate is replaced by          sodium Nlauroyl sarcosinate.                                             

The toothpastes are packaged in unlined aluminium tubes.

The surface-modifying agents mentioned above may also be incorporatedinto the toothpaste formulation without first contacting them with theabrasive. One particularly suitable agent for this purpose is pyrogenicsilica such as that sold as Aerosil or Cabosil, as illustrated in theExample below:

EXAMPLE 21

A toothpaste is prepared from about 20.2% glycerine, 0.9% sodiumcarboxymethyl cellulose, 0.2% saccharin, 46% trihydrate (Baco AF-260),2.5% pyrogenic silica, 1.54% sodium lauroyl sarcosinate, 0.8% flavor andthe balance water. The initial pH of the toothpaste is about 7.8. Whenpacked in unlined aluminium tubes it does not corrode or gas on agingfor 3 months at 43° C.

The Aerosil 200 is a hydrophilic pyrogenic silica having an acidicreaction. Typically the grade 200 has a BET surface area of 200±25 m² /gand a pH (in 4% slurry in water) of about 3.6 to 4.3 Detaileddescriptions of this material are found in publications of themanufacturer, Degussa; see for instance Kautschuk und Summi, Kunststaffe20 (1967) p. 578-586. The Aerosil particles have silanol groups at theirsurfaces and, in aqueous dispersion, the particles move, under theinfluence of an electric field, to the positive pole, i.e. they carry anegative charge.

As illustrated above, the toothpastes generally contain an aqueousvehicle including a gelling agent and a detergent or surface-activeagent, together with flavor and sweetener, besides the alpha-aluminatrihydrate. Other ingredients may be present as well. Naturally thoseskilled in the art should select such ingredients and in suchproportions as not to adversely affect the operability of theformulations for the purpose at hand.

Organic surface-active agents may be used in the dentifrice to achieveincreased prophylactic action, assist in achieving thorough and completedispersion of the compositions throughout the oral cavity, and renderthe compositions more cosmetically acceptable. It is preferred to employas the surface-active agent a detersive material which imparts to thedentifrice detersive and foaming properties. The proportion ofsurface-active agent is generally within the range of about 0.05 to 5%more usually within the range of about 0.5 to 3% such as about 1 to 2%.As indicated above, a particularly preferred surface-active agent ordetergent is an N-acyl sarcosine surfactant having at least about 10carbon atoms (e.g. 12-18 carbon atoms) in the acyl group, such as sodiumN-lauroyl sarcosinate. It is also within the scope of the invention touse other amide-linked carboxylic surfactants such higher aliphatic acylamides of lower aliphatic amino carboxylic acid compounds (such as thosehaving, say 12 to 16 or 18 carbon atoms in the higher acyl radical whichis preferably of the saturated type, and up to 4 carbon atoms in theamino carboxylic portion) and including those disclosed at pages 37 to29 of Schwartz and Perry Surface Active Agents and Detergents Volume IIpublished 1958 by Interscience Publishers. The amide-linked carboxylicsurfactant may be substantially the sole surface-active agent; in thebroader scope of that aspect of the invention there may also be presentother anionic and amphoteric or non-ionic surface-active agents,preferably in minor amounts in relation to the amide-linked surfactant(such as less than about 1% of the total toothpaste formulation, e.g.0.7% or 0.5%).

The anionic detergents include water-soluble salts of higher (i.e.having at least 12 carbon atoms) fatty acid monoglyceride monosulphates,such as the sodium salt of the monosulphated monoglyceride ofhydrogenated coconut oil fatty acids, higher alkyl sulphates, such assodium lauryl sulphate, alkyl aryl sulphonates, such as sodium dodecylbenzone sulphonate, olefin sulphonates, such as sodium olefin sulphonatein which the olefin group contains 12-21 carbon atoms, higher alkylsulphoacetates, higher fatty acid esters of 1,2-dihydroxy propanesulphonates.

The nonionic surface-active agents include such materials as condensatesof sorbitan monostearate with approximately 60 moles of ethylene oxidewith propylene oxide condensates of propylene glycol("Pluronics"--PLURONIC is a Trade Mark), other examples of suitablenonionic detergents are condensation products of alkyl phenols withethylene oxide, e.g. the reaction product of iso-octyl phenol with 6 to30 ethylene oxide units; condensation products of alkyl thiophenols with10 to 15 ethylene oxide units; condensation products of higher fattyalcohols and monoesters of hexahydric alcohols and inner ethers thereofsuch as sorbitan monolaurate, sorbitol mono-oleate and mannitanmonopalmitate.

Examples of amphoteric detergents are N-alkyl-betaaminopropionic acid;and N-alkyl-beta imino-dipropionic acid; and N-alkyl, N,N-dimethylglycine. The alkyl group may be, for example, that derived from cocofatty alcohol, lauryl alcohol, myristyl alcohol (or a lauryl-myristylmixture), hydrogenated tallow alcohol, cetyl alcohol, stearyl alcohol orblends of such alcohols. The substituted amino-propionic andiminodipropionic acids are often supplied as the sodium or other saltforms, which may likewise be used in the practice of this invention.Examples of other amphoteric detergents are betaines containing asulphonic group instead of the carboxylic group; betaines in which thelong chain substituent is joined to the carboxylic group without anintervening nitrogen atom, e.g. inner salts of 2-trimethylamino fattyacids such as 2-trimethyaminolauric acid, and compounds of any of thepreviously mentioned types in which the nitrogen atom is replaced byphosphorus.

It is also within the broader scope of the invention to employ acationic surface-active agent or detergent. Examples of these arediamines such as those of the type

    RHNC.sub.2 H.sub.4 NH.sub.2

wherein R is an alkyl group of 12 to 22 carbon atoms such asN-2-aminoethyl stearyl amine and N-2-aminoethyl myristyl amine;amido-linked amines such as those of the type R¹ CONHC₂ H₄ NH₂ whereinR¹ is an alkyl group of 9 to 20 carbon atoms, such as N-2-aminoethyl-stearyl amide and N-amino ethyl myristyl amide; quaternaryammonium compounds wherein typically one of the groups linked to thenitrogen atom is an alkyl group which contains an alkyl group of 10 to18 carbon atoms and each of the other alkyl groups typically contains 1to 3 carbon atoms and which may bear inert substituents such as phenylgroups, and there is present an anion such as halogen, acetate ormethosulphate. Typical quaternary ammonium detergents areethyl-dimethyl-stearyl ammonium chloride, benzyl-dimethyl myristylammonium chloride, benzyl-dimethylstearyl ammonium bromide, trimethylstearyl ammonium chloride, trimethylcetyl ammonium bromide,dimethyl-ethyl dilauryl ammonium chloride, dimethyl-propyl-myristylammonium chloride and the corresponding methosulphates and acetates.Other cationic surface active germicides and antibacterial compoundssuch as diisobutylphenoxyethoxyethyl dimethyl benzyl ammonium chloride,benzyl dimethyl stearyl ammonium chloride, tertiary amines having onefatty alkyl group (of from 12-18 carbon atoms) and two (poly)oxyethylene groups attached to the nitrogen (typically containing atotal of from 20 to 50 ethanoxy groups per Molecule) and salts thereofwith acids, and compounds of the structure. ##STR1## wherein R² is afatty alkyl group typically containing from 12 to 18 carbon atoms, andx, y, and z total 3 or higher, as well as salts thereof with mineral ororganic acids, may also be used.

The aqueous vehicle of the dentifrice preferably forms, with theabrasive particles, a mass of a consistency which can be extruded from acollapsible aluminium tube. The vehicle will generally contain liquidsand solids. In general, the liquid portion comprises water, glycerine oraqueous sorbitol, including suitable mixtures thereof. It is usuallyadvantageous to use a mixture of both water and a humectant such asglycerine or sorbitol. The total liquid content is generally 20-90% byweight of the dentifrice and typically includes up to 30% by weight ofwater, 0-80% by weight of glycerine and 0-80% by weight of sorbitol.Preferably up to 20% by weight of water, 15-40% by weight of glycerineand 0-50% by weight of sorbitol are present in the dentifrice.

The solid portion of the vehicle may be a gelling agent, such as thenatural and synthetic gums and gum-like materials, such as Irish Moss,gum tragacanth, alkali metal carboxymethyl cellulose and hydroxyethylcarboxyl-methyl cellulose, polyvinyl pyrrolidone, starch water soluble,hydrophilic colloidal carboxyvinyl polymers, such as those sold underthe trademark Carbopol 934 and 940 and synthetic inorganic silicateclays such as those sold under the trademark Laponite CP and LaponiteSP. These grades of Laponite have the formula

    (Si.sub.8 Mg.sub.5.1 Li.sub.0.6 H.sub.7.6 O.sub.24).sup.0.6- Ma.sup.+.sub.0.6.

The solid portion of the vehicle is typically present in amount up to10% by weight of the dentifrice and preferably 0.5-5% by weight. Whenemployed, grades of Laponite are preferably used in amount of 1-5% byweight.

Any suitable flavoring or sweetening materials may be employed informulating a flavor for the dentifrice. Examples of suitable flavorconstituents include flavoring oils, e.g. oils of spearmint, peppermint,wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon,lemon and orange, as well as methylsalicylate. Suitable sweeteningagents include sucrose, lactose, maltose, sorbitol, perillartine andsaccharine. Suitably, flavor and sweetening agents may togetherconstitute from 0.01 to 5% or more of the dentifrice. Chloroform mayalso be used.

It is also within the scope of the invention (particularly the aspectsin which the surface of the trihydrate is modified and/or when a mixtureof the monofluorophosphate and fluoride is used) to employ a lessalkaline milled alpha-alumina trihydrate in place of part (e.g. 1/4, 1/2or 3/4) or all of the highly alkaline material.

In the broader aspects of the invention, particularly with respect tosurface-modified material, the alumina trihydrate need not be the soleabrasive in the dentifrice. Other dental abrasives which may also bepresent include calcium carbonate, magnesium carbonate, tricalciumphosphate, dicalcium phosphate dihydrate, insoluble sodiummetaphosphate, calcium pyrophosphate, synthetic amorphous complexaluminosilicates, silica (including dehydrated silica gel.) The totalamount of abrasive including ground trihydrate will usually be in therange from 10 to 60%, preferably 20 to 60% by weight of the dentifrice.The alkali metal monofluorophosphates which may be employed includesodium monofluorophosphate, lithium monofluorophosphate, potassiummonofluorophosphate and ammonium monofluorophosphate. The preferred saltis sodium monofluorophosphate, Na₂ PO₃ F, which, as commerciallyavailable, may vary considerably in purity. It may be used in anysuitable purity provided that any impurities do not substantiallyadversely affect the desired properties. In general, the purity isdesirably at least 80%. For best results, it should be at least 85%, andpreferably at least 90% by weight as sodium monofluorophosphate with thebalance being primarily impurities or by products of manufacture such assodium fluoride and water-soluble sodium phosphate salt. Expressed inanother way, the sodium monofluorophosphate typically has a totalfluoride content of above 12%, preferably above 12.7%, a content of upto 1.5%, typically up to 1.2% of free sodium fluoride; and a sodiummonofluorophosphate content of at least 12%, preferably at least 12.1%all calculated as fluorine. Other monofluorophosphate salts which may beused include monofluorophosphates such as Na₄ P₃ O₉ F, K₄ P₃ O₉ F,(NH₄)₄ P₃ O₉ F, Na₃ KP₃ O₉ F, (NH₄)₃ NaP₃ O₉ F, and Li₄ P₃ O₉ F. In thebroader aspects of the invention various other materials may beincorporated in the dentifrices. Examples thereof are coloring orwhitening agents or dyestuffs, preservatives, silicones, chlorophyllcompounds, ammoniated materials such as urea, diammonium-phosphate andmixtures thereof, antibacterials and other constituents. The adjuvantsare incorporated in the compositions in amounts which do notsubstantially adversely affect the properties and characteristicsdesired. When antibacterials are present, typically the amount is0.01-5% by weight. Typical antibacterial agents includeN'-(4-chlorbenzyl)-N⁵ -(2,4-dichlorobenzyl) biguanide; p-chlorophenylbiguanide; 4-chlorobenzhydryl biguanide; 4-chlorobenzhdrylguanylurea;N-3-lauroxypropyl-N⁵ -p-chlorobenzylbiguanide;1,6-di-p-chlorophenylbiguanidohexane; 1,6-bis(2-ethylhexlbiguanido)hexane; 1-(lauryldimethylammonium)-8-(p-chlorobenzyl-dimethylammonium)octane dichloride; 5,6-dichloro-2-guanidinobenzimidazole; N¹-p-chlorophenyl-N⁵ -laurylbiguanide;5-amino-1,3-bis(2-ethylhexyl)-5-methylhexahydro pyrimidine; and theirnon-toxic acid addition salts. Still in the broader aspects of theinvention the pH of the toothpaste may be adjusted as desired, as byinclusion of appropriate amounts of acidic materials (e.g. benzoic acid,citric acid or aluminium sulphate. Generally the toothpaste pH will bein the range of about 5 to 9, determined directly on the paste,preferably about 6 to 8, such as about 6.0, 6.5, 7.0 etc.

Other dentifrice ingredients may also be present if desired, inappropriate conventional proportions. For disclosures of suchingredients and of proportions of ingredients employed in toothpastes,see British patent specifications Nos. 1,249,742, 1,188,353 and1,260,332.

It is understood that in accordance with generic aspects of thisinvention, additional dentally acceptable polishing materials may beground with a surface-modifying agent as described in order to increasetheir stability characteristics in toothpastes and containers therefor.Thus, the foregoing specific examples are typical, but should not betaken as limitations on the invention.

In this application all proportions are by weight unless otherwiseindicated. In the Examples room temperature is employed unless otherwiseindicated.

What is claimed is:
 1. A toothpaste characterized in that the toothpastecontains abrasive particles of milled alpha-alumina trihydrate, alkalimetal monofluorophosphate and alkali metal fluoride, the mol ratio ofsaid monofluorophosphate to said alkali metal fluoride being about 1.5:1to 5:1 the total amount of said monofluorophosphate and fluoridecorresponding to about 500 to 1500 ppm F, and said alpha-aluminatrihydrate being reactive with said alkali metal fluoride.
 2. Atoothpaste as in claim 1 in which the average particle size of milledalpha-alumina trihydrate is about 2 to 15 microns.
 3. A toothpaste as inclaim 2 in which said total amount is at least about 800 ppm F.
 4. Atoothpaste as in claim 3 in which said mol ratio is about 1.5:1 to1.3:1.
 5. A toothpaste as in claim 4 in which said alkali metalmonofluorophosphate is sodium monofluorophosphate and said alkali metalfluoride is sodium fluoride.